Galectins klyosov anatole a witczak zbigniew j platt david. Carbohydrate Drug Design 2019-01-24

Galectins klyosov anatole a witczak zbigniew j platt david Rating: 8,1/10 1942 reviews

Galectins

galectins klyosov anatole a witczak zbigniew j platt david

Witczak, PhD, has extensive industrial and academic experience in carbohydrates. Klyosov and Eliezer Zomer 4. Then galectin-1 was captured from a spiked cell lysate that is added to the microarray and the unbound proteins are washed away. Galectins are therefore excellent targets for tumor diagnostics and medical prognostic purposes. Food-Related Carbohydrate Ligands for Galectins Valeri V. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications.

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Galectins. Edited by Anatole A. Klyosov, Zbigniew J. Witczak and David Platt

galectins klyosov anatole a witczak zbigniew j platt david

Stumbling on Galectins Samuel H. Carbohydrate Drug Design Edited by Anatole A. Understanding Galectin Structure-Function Relationships to Design Effective Antagonists Irina V. These roles can be varied, as has been shown particularly for galectin-3. In 2014 he became Foreign Member of the National Academy of Sciences of Georgia. Structural aspects of binding of alpha-linked digalactosides to human galectin-1.

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Galectins edited by Anatole A. Klyosov, Zbigniew J. Witczak, David Platt

galectins klyosov anatole a witczak zbigniew j platt david

Witczak was awarded the Melville L. From 1979 to 1981 he was professor in the department of chemical enzymology at Moscow State University. Carbohydrate Drug Design discusses pre-clinical studies and clinical trials of carbohydrate-based drugs, drug delivery and pain managements, biocompatibility, clearance and metabolic pathways of carbohydrate drugs, and actual medical devices employing carbohydrates. Klyosov, PhD, is Chief Scientist and cofounder of Pro-Pharma-ceuticals, Inc. Development of Polysaccharide as a vehicle to improve the efficacy of chemotherapeutics David Platt, Anatole A. Besides these, a chemical probe-based method also shows potential as an alternative. Since galectins bind beta-galactosides, monovalent galactose-derived inhibitors have been prepared but also peptidic ones have appeared.

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Anatole Klyosov's Publications

galectins klyosov anatole a witczak zbigniew j platt david

To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Several ligands based on lactose and lactosamine were designed and tested. Carbohydrate Drug Design provides the indispensable understanding of the mutual challenge between carbohydrate-based drugs and the deadly diseases which they target. Since galectins often induce crosslinking and partake in aggregation phenomena, multivalency has been a successful design element in inhibitor development. Considering the importance of protein-carbohydrate interactions in biological processes, effective interference with these interactions may prove to be a powerful way towards novel therapeutics. Galectins and their Functions in Plain Language Anatole A.

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Anatole Klyosov

galectins klyosov anatole a witczak zbigniew j platt david

Witczak, PhD, has extensive industrial and academic experience in carbohydrates. Carbohydrate Research, 352, 65-69, 2012. Het detecteren van bepaalde eiwitten in complexe mengsels, als in cellen, is in dit verband van belang voor biomedisch onderzoek maar ook voor diagnose van patiënten. . Происхождение славян и других народов. The chapters provide researchers with a solid overview of the state of the art in the various subjects and will be useful to many galectin researchers. Pro-Pharmaceuticals via the Free Online Library.

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Galectins

galectins klyosov anatole a witczak zbigniew j platt david

Galectins are however also highly overexpressed in various processes related to cancer, including apoptosis, angiogenesis and metastasis. The comprehensive guide to the current understanding of galectins and their promising potential in drug design This is the first book focusing on galectins. These results are truly promising for the use of the newly developed galectin detection technology in a clinical setting. Development of a new and sensitive detection technology for galectin cancer proteins. Multivalency is an important principle that characterizes these interactions and is likely a required design principle for the synthesis of molecules with the goal to interfere effectively.

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Galectins : Anatole A. Klyosov : 9780470373187

galectins klyosov anatole a witczak zbigniew j platt david

Galactomannans and hyaluronans, as well as thio-, imino- and carba-sugars are particularly considered with respect of their structural and functional impacts. Practical Applications of Computational Stuides of the Glycosylation Reaction, Dennis M. He has published more than ninety research papers and holds six patents in the fields of carbohydrate, medicinal, and biological chemistry. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Food-Related Carbohydrate Ligands for Galectins Valeri V. Catholic Polysaccharides in the Treatment of Pathogenic Candida Infections, Avital Mazar Ben-Josef, David Platt, and Eliezer Zomer New Approaches in Synthesis and Computational Studies 9.

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Galectins. Edited by Anatole A. Klyosov, Zbigniew J. Witczak and David Platt

galectins klyosov anatole a witczak zbigniew j platt david

Aangezien dit bij galectine-3 het sterkst het geval is richt ons onderzoek zich op het detecteren van galec- tine-3 in complexe eiwitmengsels, met als hoofddoel de simpele en nauwkeurige detectiemethode van galectine-3 in kankerweefsels, gezonde weefsels en lichaamsvloeistoffen. Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia James C. Galectins in Regulation of Inflammation and Immunity Fu-Tong Liu, Daniel K. Witczak was awarded the Melville L. In 1989 he was made a fellow of the. De oorzaak van een ziekte wordt steeds vaker ge- zocht in het al dan niet aanwezig zijn van bepaalde eiwitten. He has published more than ninety research papers and holds six patents in the fields of carbohydrate, medicinal, and biological chemistry.

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Anatole Klyosov

galectins klyosov anatole a witczak zbigniew j platt david

The chapters provide researchers with a solid overview of the state of the art in the various subjects and will be useful to many galectin researchers. Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design Hans-J. Galectins in Malignant Gliomas: Expression, Functions and Possible Therapeutic Options Herwig M. The galectin presence is subsequently quantified with a general fluorescent ligand that is only bound by active galectins. He has published peer-reviewed articles and holds many patents, primarily in the field of carbohydrate chemistry. Galectins includes: An overview of early galectin research An explanation of the nature of galectins A discussion of the structure and functions of galectins, their ligand specificity and molecular mechanisms of action, and the localization of galectins in the cell An exploration of the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity A discussion of the effect of galectins on cell migration, angiogenesis, and chemoresistance An introduction to new approaches to designing galectin inhibitors This is the premier reference on galectins for organic, medicinal, carbohydrate, and pharmaceutical chemists, biochemists, molecular and cell biologists, pharmacologists, cancer researchers, and graduate-level students in these disciplines, as well as clinicians and drug developers. Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design Hans-J.

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